Wearable Device Quantifies Tissue Stiffness While Preserving Surgeon’s Sense of Touch

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Researchers have developed the first wearable probe that enhances the sense of touch by imaging and quantifying the stiffness and elasticity of biological tissue. The device is being developed to improve the surgical removal of breast cancer and might also be useful for brain and liver surgery and other types of cancer.

Image Caption: A new wearable probe enhances the sense of touch by imaging and quantifying the stiffness and elasticity of biological tissue. The device could help improve the surgical removal of breast cancer and other types of cancer. Credit: Rowan W. Sanderson, University of Western Australia

In The Optical Society (OSA) journal Biomedical Optics Express, researchers from the University of Western Australia (UWA) describe the new device, which incorporates a fiber probe into a wearable thimble.

During breast conserving surgery, the most common surgical treatment for breast cancer, surgeons touch and compress tissue to confirm that the stiffer cancerous tissue was removed. Histopathological testing is then performed days later to ensure that the whole tumor was removed. Today, 20-30% of patients undergoing this type of surgery require another procedure because the histopathological tests show that cancerous cells remain.

“Our new probe aims to enhance the surgeon’s subjective sense of touch through quantified, high-resolution imaging of tissue stiffness,” said Rowan W. Sanderson, first author of the paper. “This could make it easier to detect and remove all the cancerous tissue during the first breast conserving surgery, which would reduce the physical and psychological burden and cost that accompanies re-excision.”

Turning Touch Into Images

The finger-mounted probe uses a technique called quantitative micro-elastography (QME) to translate the sense of touch into high-resolution images. QME uses measurements from an optical imaging technique called optical coherence tomography (OCT), which generates high-resolution, depth-resolved images of tissue structure by measuring the reflections, or ‘echoes,’ of light.

To use the device, the finger-mounted probe is pressed perpendicularly into the tissue while OCT images are recorded. “By preserving the sense of touch, we aim to conserve the existing clinical workflow and increase the likelihood that this technology would be adopted for wider clinical use,” said Sanderson.

For accurate elasticity measurements, the researchers developed new signal processing methods with custom algorithms to deal with inconsistent motion and pressure during scanning. 3D printing helped them quickly produce prototypes of the probe’s outer casing in a simple and cost-effective manner.

“Our finger-mounted probe can accurately detect microscale changes in stiffness, which are indicative of disease,” said Sanderson. “The small size makes it ideal for imaging in confined spaces such as a surgical cavity.”

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