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Diblock copolypeptoids are composed of two peptoid blocks, one that’s hydrophobic one that’s hydrophilic. The scientists discovered both blocks crystallize when they meet in water, and form rings consisting of two to three individual peptoids. The rings then form hollow nanotubes.
Cryo-electron microscopy imaging of 50 of the nanotubes showed the diameter of each tube is highly uniform along its length, as well as from tube to tube. This analysis also revealed a striped pattern across the width of the nanotubes, which indicates the rings stack together to form tubes, and rules out other packing arrangements. In addition, the peptoids are thought to arrange themselves in a brick-like pattern, with hydrophobic blocks lining up with other hydrophobic blocks, and the same for hydrophilic blocks.
“Images of the tubes captured by electron microscopy were essential for establishing the presence of this unusual structure,” says Balsara. “The formation of tubular structures with a hydrophobic core is common for synthetic polymers dispersed in water, so we were quite surprised to see the formation of hollow tubes without a hydrophobic core.”
X-ray scattering analyses conducted at beamline 7.3.3 of the Advanced Light Source revealed even more about the nanotubes’ structure. For example, it showed that one of the peptoid blocks, which is usually amorphous, is actually crystalline.
Remarkably, the nanotubes assemble themselves without the usual nano-construction aids, such as electrostatic interactions or hydrogen bond networks.
“You wouldn’t expect something as intricate as this could be created without these crutches,” says Zuckermann. “But it turns out the chemical interactions that hold the nanotubes together are very simple. What’s special here is that the two peptoid blocks are chemically distinct, yet almost exactly the same size, which allows the chains to pack together in a very regular way. These insights could help us design useful nanotubes and other structures that are rugged and tunable—and which have uniform structures.”
The Advanced Light Source and the Molecular Foundry are DOE Office of Science User Facilities located at Berkeley Lab.
The research was supported by the Department of Energy’s Office of Science.
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